Анагрелид






























Анагрелид
Anagrelide.svg
Анагрелид
Химическое соединение
Брутто-формула
C₁₀H₇Cl₂N₃O
CAS
68475-42-3
PubChem
2182
DrugBank
00261
АТХ
L01XX35

Анагрелид, (Anagrelide), агрилин, производное имидазоквиназолина, лекарственный препарат, используемый при увеличении количества тромбоцитов в крови (эссенциальный тромбоцитоз, истинная полицитемия и другие).




Содержание






  • 1 Механизм действия


  • 2 Применение


  • 3 Побочные эффекты


  • 4 Примечания





Механизм действия |


Точный механизм действия препарата не установлен. В отношении препарата известно, что он тормозит синтез фосфодиэстеразы. Предполагают, что при полицитемии анагрелид препятствует созреванию мегакариоцитов в тромбоциты.



Применение |


Препарат применяется для лечения истинной полицитемии в дозе 0,5-3 мг в день. Проведённые сравнительные исследования комбинаций анагрелида с аспирином и гидроксимочевины с аспирином при истинной полицитемии показали лучшее действие гидрооксимочевины с аспирином на профилактику миелофиброза, артериального тромбоза и кровотечений. В то же время эта комбинация повышала уровень венозных тромбозов.


Сочетание же анагрелида с аспирином увеличивало риск кровотечений.[1]



Побочные эффекты |


Из побочных эффектов отмечаются головная боль, диарея, слабость, тошнота, головокружение



Примечания |




  1. ↑ Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR; United Kingdom Medical Research Council Primary Thrombocythemia 1 Study. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005;353:33-45. PMID 16000354.








Таблетки
Это заготовка статьи о лекарственных средствах. Вы можете помочь проекту, дополнив её.



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